Structure of PDB 6mzf Chain A

Receptor sequence
>6mzfA (length=423) Species: 9823 (Sus scrofa) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDSFNTFFSETGAG
KHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYT
IGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSV
DYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAI
YDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNL
VPYPRAHFPLATYAPVISAEQLSVAEITNACFEPANQMVKCDPRHGKYMA
CCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVP
GGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGME
EGEFSEAREDMAALEKDYEEVGV
3D structure
PDB6mzf Structural basis of tubulin recruitment and assembly by microtubule polymerases with Tumor Overexpressed Gene (TOG) domain arrays.
ChainA
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A G10 Q11 A12 Q15 A99 N101 S140 G143 G144 T145 G146 I171 V177 E183 N206 Y224 N228 G9 Q10 A11 Q14 A90 N92 S131 G134 G135 T136 G137 I162 V168 E174 N197 Y215 N219
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0031514 motile cilium

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Cellular Component
External links
PDB RCSB:6mzf, PDBe:6mzf, PDBj:6mzf
PDBsum6mzf
PubMed30422110
UniProtP02550|TBA1A_PIG Tubulin alpha-1A chain (Gene Name=TUBA1A)

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