Structure of PDB 6myr Chain A

Receptor sequence

>6myrA (length=611) Species: 9031 (Gallus gallus) [Search protein sequence]

QYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAA
QGGINAALGNMEDDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVIEL
ENYGMPFSRTEEGKIYQRAFGGQSLQFGKGGQAHRCCCVADRTGHSLLHT
LYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGTIHRFRAKNTV
IATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGA
GCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTIEIRE
GRGCGPEKDHVYLQLHHLPPQQLATRLPGISETAMIFAGVDVTKEPIPVL
PTVHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEAASASVHGANRLG
ANSLLDLVVFGRACALTIAETCKPGEPVPSIKPNAGEESVANLDKLRFAD
GTIRTSEARLNMQKTMQSHAAVFRTGSILQEGCEKLSQIYRDLAHLKTFD
RGIVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKLRIDE
FDYSKPLQGQQKRPFEEHWRKHTLSYVDVKSGKVTLKYRPVIDRTLNEED
CSSVPPAIRSY

3D structure

PDB

6myr Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.

Chain

Resolution

2.15 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F130 Q251 H253 L263 E266 R269 R297 H364 Y365 R408
Catalytic site (residue number reindexed from 1)	F120 Q241 H243 L253 E256 R259 R287 H354 Y355 R398
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G25 A26 G27 T48 K49 L50 S55 H56 T57 A59 A60 Q61 G62 G63 Y176 F177 A178 T213 G214 D232 L263 H364 Y365 E397 A411 S413 L414 L417	G15 A16 G17 T38 K39 L40 S45 H46 T47 A49 A50 Q51 G52 G53 Y166 F167 A168 T203 G204 D222 L253 H354 Y355 E387 A401 S403 L404 L407
BS02	OAA	A	G62 F130 H253 T265 E266 R297 H364 R408 G410 A411	G52 F120 H243 T255 E256 R287 H354 R398 G400 A401

Gene Ontology

	Molecular Function
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6myr, PDBe:6myr, PDBj:6myr
PDBsum	6myr
PubMed	34089891
UniProt	Q9YHT1\|SDHA_CHICK Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)

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