Structure of PDB 6myn Chain A

Receptor sequence
>6mynA (length=322) Species: 10090 (Mus musculus) [Search protein sequence]
PVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYRE
EVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVACA
GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYY
LGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQSLL
TGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFR
GPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKV
GKALQEVGGLKSPWKGEYKEPR
3D structure
PDB6myn Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).
ChainA
Resolution2.744 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 L553
Catalytic site (residue number reindexed from 1) D170 L200
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K6Y A R410 G411 V416 A429 V455 M471 E472 L473 L474 G477 L524 C535 D536 F537 R63 G64 V69 A82 V108 M124 E125 L126 L127 G130 L177 C188 D189 F190 PDBbind-CN: -logKd/Ki=7.85,Ki=14nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6myn, PDBe:6myn, PDBj:6myn
PDBsum6myn
PubMed31531194
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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