Structure of PDB 6mxt Chain A

Receptor sequence
>6mxtA (length=449) Species: 9606,10665 [Search protein sequence]
GNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVI
TTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQ
TVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVL
CVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS
FLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIM
VFVYSRVFQEAKRQLQKIDKFCLKEHKALKTLGIIMGTFTLCWLPFFIVN
IVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL
3D structure
PDB6mxt Structural insights into binding specificity, efficacy and bias of a beta2AR partial agonist.
ChainA
Resolution2.95934 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K5Y A W1109 D1113 V1114 V1117 D1192 F1193 S1203 F1289 I1303 Y1308 N1312 W244 D248 V249 V252 D327 F328 S338 F396 I410 Y415 N419
BS02 MG A N1103 C1184 Y1185 E1187 C1190 N238 C319 Y320 E322 C325
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0004941 beta2-adrenergic receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006940 regulation of smooth muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mxt, PDBe:6mxt, PDBj:6mxt
PDBsum6mxt
PubMed30327561
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P07550|ADRB2_HUMAN Beta-2 adrenergic receptor (Gene Name=ADRB2)

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