Structure of PDB 6mxd Chain A

Receptor sequence
>6mxdA (length=217) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
PLKPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAY
KTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGL
PNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREY
RPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYR
HVFVLKPEYAKRYPSKL
3D structure
PDB6mxd Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP.
ChainA
Resolution2.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E147 D148 D151 Y201 R214
Catalytic site (residue number reindexed from 1) E130 D131 D134 Y184 R197
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A I149 D151 T152 G153 T155 K180 Y201 V202 I132 D134 T135 G136 T138 K163 Y184 V185 PDBbind-CN: -logKd/Ki=5.23,Ki=5.83uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0000310 xanthine phosphoribosyltransferase activity
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0042301 phosphate ion binding
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome

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Cellular Component
External links
PDB RCSB:6mxd, PDBe:6mxd, PDBj:6mxd
PDBsum6mxd
PubMed31287615
UniProtQ38CA1

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