Structure of PDB 6mx3 Chain A

Receptor sequence
>6mx3A (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLP
LDCGVPDNLDPNIRFLDKLPQSNSIYELLENGQRAGTCVLEYATPLQTLF
AMSQYSQAGFSREDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPSF
SLSQEVLRHLRQE
3D structure
PDB6mx3 Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
ChainA
Resolution1.362 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K5P A S162 T263 P264 Q266 T267 S9 T94 P95 Q97 T98 PDBbind-CN: -logKd/Ki=5.14,IC50=7300nM
BindingDB: IC50=7300nM
BS02 K5P A S162 Y163 G166 Y167 S9 Y10 G13 Y14 PDBbind-CN: -logKd/Ki=5.14,IC50=7300nM
BindingDB: IC50=7300nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:6mx3, PDBe:6mx3, PDBj:6mx3
PDBsum6mx3
PubMed30655953
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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