Structure of PDB 6mwe Chain A

Receptor sequence
>6mweA (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
YPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMGELEVLCK
LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAI
ANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVA
KIADFGLSRGQEVYKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWE
IVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPY
ERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEE
3D structure
PDB6mwe The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D964 A966 R968 N969 D982
Catalytic site (residue number reindexed from 1) D136 A138 R140 N141 D154
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 919 A A853 K855 E872 E903 A905 L971 A981 D982 F983 G984 R987 Q989 A38 K40 E44 E75 A77 L143 A153 D154 F155 G156 R159 Q161 PDBbind-CN: -logKd/Ki=9.20,Kd=0.63nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6mwe, PDBe:6mwe, PDBj:6mwe
PDBsum6mwe
PubMed28838996
UniProtQ02763|TIE2_HUMAN Angiopoietin-1 receptor (Gene Name=TEK)

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