Structure of PDB 6mw7 Chain A

Receptor sequence
>6mw7A (length=514) Species: 9606 (Homo sapiens) [Search protein sequence]
HRTVYLFDRREKESELGDRPLQVGERSDYAGFRACVCQTLGISPEEKFVI
TTTSRKEITCDNFDETVKDGVTLYLLQSVNQLLLTATKERIDFLPHYDTL
VKSGMYEYYASEGQNPLPFALAALIDNSLSATSRNIGVRRIQIKLLFDET
QGKPAVAVIDNGRGMTSKQLNNWAVYRLSKFTRYVRPVPVPRSLNSDISY
FGVGGKQAVFFVGQSARMISKPADSQDVHELVLSKEDFEKKEKNKEAIYS
GYIRNRKPSDSVHITNDDERFLHHLIIEEKEKDSFTAVVITGVQPEHIQY
LKNYFHLWTRQLAHIYHYYIHGPKGNEINIDIEISMFEKGKVPKIVNLRE
IQDDMQTLYVNTAADSFEFKAHVEGDGVVEGIIRYHPFLYDRETYPDDPC
FPAARGKRPIFECFWNGRLIPYTSVEDFDWCTPPGLAPIECYNRISGALF
TNDKFQVSTNKLTFMDLELKLKDKNTLFTRILNGQEQRMKIDREFALWLK
DCHEKYDKQIKFTL
3D structure
PDB6mw7 A ubiquitin-like domain is required for stabilizing the N-terminal ATPase module of human SMCHD1.
ChainA
Resolution2.194 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A N151 A155 M189 W197 R207 S233 Y234 F235 G236 V237 G238 G239 K240 T320 K525 N127 A131 M165 W173 R183 S199 Y200 F201 G202 V203 G204 G205 K206 T286 K461
Gene Ontology
Biological Process
GO:0006302 double-strand break repair

View graph for
Biological Process
External links
PDB RCSB:6mw7, PDBe:6mw7, PDBj:6mw7
PDBsum6mw7
PubMed31312724
UniProtA6NHR9|SMHD1_HUMAN Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (Gene Name=SMCHD1)

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