Structure of PDB 6mv9 Chain A

Receptor sequence

>6mv9A (length=674) Species: 1423 (Bacillus subtilis)

KWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQNTVFFHNLKEKLDY
LVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYNDYALK
TNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFL
NAGRKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLR
AKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRD
INDFLDTKKISAVKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQ
HMDEMDMNEMYDKFVDNPRVKKEKINPRKLLEKLAMLRSESGYPYIMFQD
NVNKVHANNHISKVKFSNLCSEVLQASQVSSYTDYDEEDEIGLDISCNLG
SLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVRRANKAMKSIG
LGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAKEKGE
TFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLK
AFVAEHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEEKTYYPMPGL
ASNNWFFYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLN
RIDLYAHHRGIKTIYYASCLSCVV

3D structure

• PDB: 6mv9 Convergent allostery in ribonucleotide reductase.
• Chain: A
• Resolution: 2.95 Å

Enzymatic activity

• Enzyme Commision number: 1.17.4.1: ribonucleoside-diphosphate reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TTP	A	D177 S178 L179 R207 I213 K214 T220	D170 S171 L172 R200 I206 K207 T213
BS02	ADP	A	V33 H34 F37 R90 F91	V26 H27 F30 R83 F84
BS03	TTP	A	K194 Y236	K187 Y229

Gene Ontology

Molecular Function

• GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
• GO:0005524 ATP binding
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0009263 deoxyribonucleotide biosynthetic process

Cellular Component

• GO:0005971 ribonucleoside-diphosphate reductase complex

External links

• PDB: RCSB:6mv9, PDBe:6mv9, PDBj:6mv9
• PDBsum: 6mv9
• PubMed: 31201319
• UniProt: P50620|RIR1_BACSU Ribonucleoside-diphosphate reductase subunit alpha (Gene Name=nrdE)