Structure of PDB 6mv1 Chain A

Receptor sequence

>6mv1A (length=355) Species: 9606 (Homo sapiens)

SYPSYDWFQTDSLVTIAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLY
LIHIGLSHEVQEDFSVRVVESVGKIEIVLQKKENTSWDFLGHPLKNHNSL
IPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPSTHLQVPIGQHVYLKL
PITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLFTPELD
RLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTD
IPSLRKVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNG
KQGHISPALLSEFLKRNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNE
IHSFT

3D structure

• PDB: 6mv1 Crystal structures of the naturally fused CS and cytochrome b5reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+nicotinamide ring.
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 1.6.2.2: cytochrome-b5 reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	H310 K324 P325 Y326 T327 Y355 T357 G358 L359 F360 T361 T400 T403	H145 K159 P160 Y161 T162 Y190 T192 G193 L194 F195 T196 T235 T238
BS02	NAD	A	K353 Y355 A398 G399 T400 G401 F427 N428 K429 S457 H469 C493 G494 P495 P497 F519 T520	K188 Y190 A233 G234 T235 G236 F262 N263 K264 S292 H304 C328 G329 P330 P332 F354 T355

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity

External links

• PDB: RCSB:6mv1, PDBe:6mv1, PDBj:6mv1
• PDBsum: 6mv1
• PubMed: 31282472
• UniProt: Q7L1T6|NB5R4_HUMAN Cytochrome b5 reductase 4 (Gene Name=CYB5R4)