Structure of PDB 6mus Chain A

Receptor sequence
>6musA (length=772) Species: 342948 (Thermococcus onnurineus) [Search protein sequence]
EIDELTALGGLLANIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEYE
LLSLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEAD
NLASGERPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYR
ELVKRLWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMT
SAIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGT
LKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPD
AVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEA
RKRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSA
SDPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYL
QGGRPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEEL
SMASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGA
IIEGKFGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFR
VRRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRV
FVVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGL
LWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVER
KEPQPVYWVDGVLKIVLMAVRR
3D structure
PDB6mus Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R630 S701 R777 R625 S696 R772
BS02 ZN A C389 C413 C384 C408
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6mus, PDBe:6mus, PDBj:6mus
PDBsum6mus
PubMed30503773
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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