Structure of PDB 6mtw Chain A

Receptor sequence
>6mtwA (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVI
IDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGS
YFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQ
LYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKT
LRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTP
TINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGV
PTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQE
LPGSEHIEMLANATTLAYLKRVLLGP
3D structure
PDB6mtw Structural Basis of Lysosomal Phospholipase A2Inhibition by Zn2.
ChainA
Resolution1.999 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
3.1.1.32: phospholipase A1.
3.1.1.4: phospholipase A2.
3.1.1.5: lysophospholipase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A S165 H359 S162 H356
BS02 ZN A D307 C322 D304 C319
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008270 zinc ion binding
GO:0008374 O-acyltransferase activity
GO:0008970 phospholipase A1 activity
GO:0016411 acylglycerol O-acyltransferase activity
GO:0016746 acyltransferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047499 calcium-independent phospholipase A2 activity
GO:0052739 phosphatidylserine 1-acylhydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006651 diacylglycerol biosynthetic process
GO:0006658 phosphatidylserine metabolic process
GO:0006672 ceramide metabolic process
GO:0009062 fatty acid catabolic process
GO:0016042 lipid catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0046338 phosphatidylethanolamine catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046471 phosphatidylglycerol metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005764 lysosome
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mtw, PDBe:6mtw, PDBj:6mtw
PDBsum6mtw
PubMed30830753
UniProtQ8NCC3|PAG15_HUMAN Lysosomal phospholipase A and acyltransferase (Gene Name=PLA2G15)

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