Structure of PDB 6mse Chain A

Receptor sequence
>6mseA (length=393) Species: 9606 (Homo sapiens) [Search protein sequence]
KTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAAD
KQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTD
IEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQ
IEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRT
DACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGA
RFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMR
PGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGA
EIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSAT
3D structure
PDB6mse Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K248 Y249 K215 Y216
BS02 ATP A P218 G219 T220 G221 K222 T223 L224 N322 I354 G382 A383 P185 G186 T187 G188 K189 T190 L191 N289 I321 G349 A350
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mse, PDBe:6mse, PDBj:6mse
PDBsum6mse
PubMed30479383
UniProtP35998|PRS7_HUMAN 26S proteasome regulatory subunit 7 (Gene Name=PSMC2)

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