Structure of PDB 6mqn Chain A

Receptor sequence
>6mqnA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGIGKSALTIQLIQNHFVEDSYRKQVVIDGETCLLDILD
TAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSE
DVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFY
TLVREIRKHKE
3D structure
PDB6mqn Structural basis of the atypical activation mechanism of KRASV14I.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A G13 I14 G15 K16 S17 A18 F28 N116 K117 D119 S145 A146 K147 G13 I14 G15 K16 S17 A18 F28 N109 K110 D112 S138 A139 K140
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mqn, PDBe:6mqn, PDBj:6mqn
PDBsum6mqn
PubMed31341022
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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