Structure of PDB 6mq8 Chain A

Receptor sequence

>6mq8A (length=426) Species: 9606 (Homo sapiens)

GTGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

• PDB: 6mq8 Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase.
• Chain: A
• Resolution: 1.969 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q38 Y39 W42 K86 R93 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327 R351	Q37 Y38 W41 K85 R92 K305 R307 P310 K311 T312 G314 S316 K317 N318 P320 G321 R345
BS02	dna	A	S113 E116 S257 G259 K261 L262 R377 L381 R382	S112 E115 S251 G253 K255 L256 R371 L375 R376
BS03	0KX	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D12 M13 D14 C15 F16 F17 Y51 R54 R60 D114 K225
BS04	MG	A	D13 M14 D115	D12 M13 D114
BS05	MG	A	D13 D115 E116	D12 D114 E115

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6mq8, PDBe:6mq8, PDBj:6mq8
• PDBsum: 6mq8
• PubMed: 33258913
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)