Structure of PDB 6mo7 Chain A

Receptor sequence
>6mo7A (length=114) Species: 9606 (Homo sapiens) [Search protein sequence]
RVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDM
GTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIF
LQKVASMPQEEQEL
3D structure
PDB6mo7 Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JWA A W97 P98 F99 V103 L108 N156 I162 W24 P25 F26 V30 L35 N83 I89 PDBbind-CN: -logKd/Ki=5.03,IC50=9376nM
External links
PDB RCSB:6mo7, PDBe:6mo7, PDBj:6mo7
PDBsum6mo7
PubMed30606676
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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