Structure of PDB 6mo5 Chain A

Receptor sequence
>6mo5A (length=303) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
HHHHATIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLD
PVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVEL
SASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFVRIKREVSVEEGDKRAV
FVPFDGFKVSFEIDFDHPVFRRTQQASVDFSSTSFVKEVSRARTFGFMRD
IEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDL
YLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISY
MRP
3D structure
PDB6mo5 Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
ChainA
Resolution1.851 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JWP A L18 H19 M62 E77 H78 T190 F191 G192 F193 I197 G209 S210 H237 D241 H264 L23 H24 M67 E82 H83 T194 F195 G196 F197 I201 G213 S214 H241 D245 H268 MOAD: ic50=0.3nM
PDBbind-CN: -logKd/Ki=9.52,IC50=0.3nM
BS02 MG A H78 H237 D241 H83 H241 D245
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6mo5, PDBe:6mo5, PDBj:6mo5
PDBsum6mo5
PubMed31283109
UniProtP47205|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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