Structure of PDB 6mo2 Chain A

Receptor sequence
>6mo2A (length=164) Species: 11060 (dengue virus type 2) [Search protein sequence]
MADLELERAADVRWEEQAEISGSSLEDGAYRIKQKGILGYSQIGAGVYKE
GTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGE
EVQVLALEPGKNPRAVQTKPGLFKTNTGTIGAVSLDFSPGTSGSPIVDKK
GKVVGLYGIANTEK
3D structure
PDB6mo2 Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
ChainA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JVM A K1073 K1074 D1075 L1076 L1149 G1151 I1165 K80 K81 D82 L83 L156 G158 I159 PDBbind-CN: -logKd/Ki=6.68,IC50=0.21uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6mo2, PDBe:6mo2, PDBj:6mo2
PDBsum6mo2
PubMed31017399
UniProtA0A0B4L2Y4;
Q91H74

[Back to BioLiP]