Structure of PDB 6mny Chain A

Receptor sequence
>6mnyA (length=252) Species: 10090 (Mus musculus) [Search protein sequence]
WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIE
EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQ
TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR
YVLKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNS
EAAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDV
MD
3D structure
PDB6mny Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 R525 N526 D539
Catalytic site (residue number reindexed from 1) D127 R131 N132 D145
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JVP A L408 T410 V416 A428 K430 M449 I472 T474 M477 C481 L528 S538 D539 F540 L542 L14 T16 V22 A34 K36 M55 I78 T80 M83 C87 L134 S144 D145 F146 L148 PDBbind-CN: -logKd/Ki=8.82,IC50=1.5nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6mny, PDBe:6mny, PDBj:6mny
PDBsum6mny
PubMed30655951
UniProtP35991|BTK_MOUSE Tyrosine-protein kinase BTK (Gene Name=Btk)

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