Structure of PDB 6mn2 Chain A

Receptor sequence
>6mn2A (length=260) Species: 77133 (uncultured bacterium) [Search protein sequence]
SRVSTRSSLAEDLRAIGLADGDAVLVHAALRKVGKIVGGPDDILDAMRDV
IGPAGTVLGYADWQLEDEIRDDPAMREHIPAFDPLRSRSIRDNGFWPELI
RTTPGALRSASPGASMAAIGGEAEWFTADHALDYGYGPRSPLGKLVEAKG
KVLMLGAPLDTMTLLAHAEHLADFPNKRILRYEAPILVDGEKVWRWFEEF
DTSDPPDGLADDYFAGIVEEFLATGRGKRGKIGEASSVLVPADEIVAFAV
DWLERWGRTA
3D structure
PDB6mn2 Crystal structure of meta-AAC0038, an environmental aminoglycoside resistance enzyme, mutant H168A in abortive complex with sisomicin-CoA
ChainA
Resolution2.744 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A H29 A31 L32 R33 P42 N95 G96 F97 P160 T163 H27 A29 L30 R31 P40 N93 G94 F95 P158 T161
BS02 SIS A Y62 D64 D162 T204 S205 Y60 D62 D160 T202 S203
BS03 COA A Q66 R93 Q64 R91
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6mn2, PDBe:6mn2, PDBj:6mn2
PDBsum6mn2
PubMed
UniProtA0A059X981

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