Structure of PDB 6ml1 Chain A

Receptor sequence
>6ml1A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence]
NEQPGLCGLSNLGFMNSAIQCLSNTPPLTEYFLNDKYQEELNFDNPLGMR
GEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFCQELLAFLLDGL
HEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKRNDSIIVDIFHGLF
KSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLKDCIELFTTKEKLG
DPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRYMRDKLDTLVDF
PINDLDMSGCRYNLIAVSNHYGGHYTAFAKNKDDGKWYYFDDSSVSTASE
DQIVSKAAYVLFYQRQ
3D structure
PDB6ml1 Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W825 S826 L827 S862 G872 W221 S222 L223 S258 G259
BS02 CA A D858 Q933 D254 Q316
BS03 CA A C873 R932 C260 R315
BS04 ZN A C448 C451 C809 C812 C156 C159 C205 C208
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6ml1, PDBe:6ml1, PDBj:6ml1
PDBsum6ml1
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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