Structure of PDB 6mkq Chain A

Receptor sequence
>6mkqA (length=262) Species: 666 (Vibrio cholerae) [Search protein sequence]
NKNMADIEAAFEGRVGVYAINTGSGKAYSYRANERFPLCSSFKAFLAAAV
LKMDQDSPGVLLEKVNYHNRTMEPHSPITEKFQSQGMAVGELAAATLQYS
DNGAANLLMEKYIKGPEGMTQFMNSIGDTKFRLDRWELDLNSAIPGDERD
TSTPKAVAESLNKLISNTVLDNYHQEIFKKWMIGNTTGDNRIRAAVPDGW
VVGDKTGTCGKYGTANDHAFILQGNNAAPLILSIYTTRKGEHMKHDDEVI
AKAARIAIENVK
3D structure
PDB6mkq Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S43 K46 S103 E140 K208 T211
Catalytic site (residue number reindexed from 1) S40 K43 S100 E137 K205 T208
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NXL A C42 S43 S103 T190 T209 G210 T211 C39 S40 S100 T187 T206 G207 T208 PDBbind-CN: -logKd/Ki=6.16,Kd=0.686uM
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6mkq, PDBe:6mkq, PDBj:6mkq
PDBsum6mkq
PubMed30782990
UniProtA0A0U3IB62

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