Structure of PDB 6mju Chain A

Receptor sequence
>6mjuA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLN
TGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKNPLSQF
LEGEILSASKMLSKFRKIIKEEGSPAVTLISVDITLALESKSSWPASTQE
GLRIQNWLSAKVRKQLRLKPFYLVPKHAGFQEETWRLSFSHIEKEILNNH
GKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDEEHLDKFSSYHVKT
AFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNL
FSSNLIDKRSKEFLTKQIEYERNNEFPVFDE
3D structure
PDB6mju Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JUM A R376 S434 Y436 L490 R186 S244 Y246 L300 MOAD: ic50=0.0275uM
PDBbind-CN: -logKd/Ki=7.56,IC50=0.0275uM
BS02 ZN A H390 C396 C397 C404 H200 C206 C207 C214
External links
PDB RCSB:6mju, PDBe:6mju, PDBj:6mju
PDBsum6mju
PubMed31113940
UniProtQ8N884|CGAS_HUMAN Cyclic GMP-AMP synthase (Gene Name=CGAS)

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