Structure of PDB 6mh1 Chain A

Receptor sequence
>6mh1A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB6mh1 Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JQP A W81 F83 V87 L92 L94 Y97 C136 N140 I146 W40 F42 V46 L51 L53 Y56 C95 N99 I105 MOAD: ic50=1.7uM
PDBbind-CN: -logKd/Ki=5.92,Kd=1.2uM
BindingDB: Kd=1200nM,IC50=1700nM
External links
PDB RCSB:6mh1, PDBe:6mh1, PDBj:6mh1
PDBsum6mh1
PubMed30253095
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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