Structure of PDB 6mga Chain A

Receptor sequence

>6mgaA (length=429) Species: 9606 (Homo sapiens)

VVYKVPEEQPPNTLIGSLAADLYKLEVGAPYLRVDGKTGDIFTTETSIDR
EGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPN
FASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELF
GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLR
VTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEY
TFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPK
SARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALV
QVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYE
KVKDYTIEIVAVDSGNPPLSSTNSLKVQV

3D structure

• PDB: 6mga Identification of an adhesive interface for the non-clustered delta 1 protocadherin-1 involved in respiratory diseases.
• Chain: A
• Resolution: 3.15 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E9 E10 D59 E61 D106	E7 E8 D49 E51 D96
BS02	CA	A	E9 E61 D103 I104 D106 D139	E7 E51 D93 I94 D96 D129
BS03	CA	A	N105 N107 D137 D139 N143 D197	N95 N97 D127 D129 N133 D187
BS04	CA	A	E122 D182 E184 D218	E112 D172 E174 D208
BS05	CA	A	E122 E184 D215 T216 D218 D251	E112 E174 D205 T206 D208 D241
BS06	CA	A	N217 N219 D249 D251 N255 D304	N207 N209 D239 D241 N245 D294
BS07	CA	A	E234 D289 E291 D325	E224 D279 E281 D315
BS08	CA	A	E234 E291 D322 M323 D325 D366	E224 E281 D312 M313 D315 D356
BS09	CA	A	N324 N326 D364 D366 N370 D423	N314 N316 D354 D356 N360 D413

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:6mga, PDBe:6mga, PDBj:6mga
• PDBsum: 6mga
• PubMed: 31583286
• UniProt: Q08174|PCDH1_HUMAN Protocadherin-1 (Gene Name=PCDH1)