Structure of PDB 6mg8 Chain A

Receptor sequence

>6mg8A (length=985) Species: 10090 (Mus musculus)

GRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANL
ETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLT
TEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIE
YLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKI
NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVAL
VLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQ
MYEHFRGYDYVSHINWNEDRAAAILEAWQRTYVEVVHQSVAPNSTQKVLP
FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGL
AGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHA
FSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALR
AFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREWTLSSFAEKHYAPFLLK
PKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFK
YFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLH
YFRDWLQGLQDAFDSDWETGRIMPNNYKNGSDDGVLAYKLLVQTGSRDKP
IDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRP
EWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRV
ICNNYTSLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVF
LLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEF
TVHVALAFLTAIGDKNHRAMLALEHMFAPVLDGAVSTLLGVLMLAGSEFD
FIVRYFFAVLAILTVLGVLNGLVLLPVLLSFFGPC

3D structure

• PDB: 6mg8 Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
• Chain: A
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	A	S192 I206 Y210 L268 V273 S317	S135 I149 Y153 L211 V216 S260
BS02	CLR	A	W115 L763 I766 F1003 W1004	W58 L581 I584 F821 W822
BS03	CLR	A	L107 V428 F481 T486	L50 V371 F424 T429
BS04	CLR	A	G91 F569	G34 F512

Gene Ontology

Molecular Function

• GO:0008158 hedgehog receptor activity

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6mg8, PDBe:6mg8, PDBj:6mg8
• PDBsum: 6mg8
• PubMed: 30415841
• UniProt: Q61115|PTC1_MOUSE Protein patched homolog 1 (Gene Name=Ptch1)