Structure of PDB 6mfb Chain A

Receptor sequence
>6mfbA (length=384) Species: 7159 (Aedes aegypti) [Search protein sequence]
KFTPPPSSLRGPLVIPDKIMMGPGPSNCSKRVLAALNNTCLSNFHDELFQ
VIDEVKDGLRYIFQTENRTTMCITGSAHTGMEALLCNLLEEGDIVLIANN
GIWAERAINMATRYGADVRVLEGPADKPFSMTDFKKAIEQHRPKCLFVVH
GDSSSGLLQPLEGLGKICHDYDCLLLVDAVASLCGVPFYMDKWEIDGVYT
GSQKVLGAPPGITPISISPKALEVIRSRKTPSKVFYWDLLILGNYWGCYD
EQKRYHHTVPSNLIFALREAIAQIAEEGLEPVIRRRQECAEQMYRGLQAM
GLEIFVKDPEYRLPTVTCIMIPKGVNWWKVSEYAMNNFSLEIQGGFGPTM
GIAWRAGIMGESSTLQRVNFYLYAFKESLKATHP
3D structure
PDB6mfb Crystal structure of 3-hydroxykynurenine transaminase from Aedes aegypti
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.6.1.44: alanine--glyoxylate transaminase.
2.6.1.63: kynurenine--glyoxylate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A S77 A78 H79 W104 S154 D179 V181 Q204 K205 S76 A77 H78 W103 S153 D178 V180 Q203 K204
BS02 PLP A Y256 T259 Y255 T258
Gene Ontology
Molecular Function
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0047315 kynurenine-glyoxylate transaminase activity
Biological Process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005777 peroxisome

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Biological Process
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Cellular Component
External links
PDB RCSB:6mfb, PDBe:6mfb, PDBj:6mfb
PDBsum6mfb
PubMed
UniProtQ0IG34|HKT_AEDAE 3-hydroxykynurenine transaminase (Gene Name=HKT)

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