Structure of PDB 6mf2 Chain A

Receptor sequence
>6mf2A (length=1222) Species: 9606 (Homo sapiens) [Search protein sequence]
ATRRYYLGAVELSWDYMQSSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLG
PTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREK
EDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLI
GALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSWPKMHTVNGYVNR
SLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISP
ITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEKHPKTWVHY
IAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDET
FKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRP
LYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSS
FVNMERDLASGLIGPLLICYKRNVILFSVFDENRSWYLTENIQRFLPNPA
GVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFL
SVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRN
RGMTALLKVSSCKKTRHYFIAAVERLWDYGMSVPQFKKVVFQEFTDGSFT
QPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEE
DPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSG
LIGPLLVCHTNTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMEREDP
TFKENYRFHAINGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSG
HVFTVRKKEEYKMALYNLYPGVFETVEMLPSKAGIWRVECLIGEHLHAGM
STLFLVYSNKCQTPLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSIN
AWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGK
KWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS
TLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARL
HLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEF
LISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHP
QSWVHQIALRMEVLGCEAQDLY
3D structure
PDB6mf2 The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.
ChainA
Resolution3.60936 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K107 E122 D125 D126 K84 E99 D102 D103
BS02 ZN A H267 H317 M320 H227 H277 M280
BS03 CU1 A H1954 I2002 H2005 H844 I892 H895
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6mf2, PDBe:6mf2, PDBj:6mf2
PDBsum6mf2
PubMed31454152
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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