Structure of PDB 6mf0 Chain A

Receptor sequence
>6mf0A (length=1256) Species: 9606,9823 [Search protein sequence]
AIRRYYLGAVELSWDYRQSELLRELHVDTRFPATAPGALPLGPSVLYKKT
VFVEFTDQLFSVARPRPPWMGLLGPTIQAEVYDTVVVTLKNMASHPVSLH
AVGVSFWKSSEGAEYEDHTSQREKEDDKVLPGKSQTYVWQVLKENGPTAS
DPPCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLTRERTQNLHEFVLLF
AVFDEGKSWHSAAQPAMHTVNGYVNRSLPGLIGCHKKSVYWHVIGMGTSP
EVHSIFLEGHTFLVRHHRQASLEISPLTFLTAQTFLMDLGQFLLFCHISS
HHHGGMEAHVRVESCAEKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKS
QYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGD
TLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIF
KYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESD
KRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSING
YVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLT
LFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCKRTRHYFI
AAVEQLWDYGMSESVPRFKKVVFREFADGSFTQPSYRGELNKHLGLLGPY
IRAEVEDNIMVTFKNQASRPYSFYSSLISYPDDQEQGAEPRHNFVQPNET
RTYFWKVQHHMAPTEDEFDCKAWAYFSDVDLEKDVHSGLIGPLLICRANT
LNAAHGRQVTVQEFALFFTIFDETKSWYFTENVERNCTLKENYRFHAING
YVMDTLPGLVMAQNQRIRWYLLSMGSNENIHSIHFSGHVFSVRKKEEYKM
AVYNLYPGVFETVEMLPSKVGIWRIECLIGEHLQAGMSTTFLVYSKKCQT
PLGMASGHIRDFQITASGQYGQWAPKLARLHYSGSINAWSTKEPFSWIKV
DLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTL
MVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS
CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQV
NNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTL
FFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEV
LGCEAQ
3D structure
PDB6mf0 The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A K108 E111 E123 D126 D127 K108 E111 E123 D126 D127
BS02 ZN A H268 C311 H318 H253 C296 H303
BS03 CU1 A H1954 C2000 H2005 H881 C927 H932
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:6mf0, PDBe:6mf0, PDBj:6mf0
PDBsum6mf0
PubMed31454152
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8);
P12263|FA8_PIG Coagulation factor VIII (Gene Name=F8)

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