Structure of PDB 6me2 Chain A

Receptor sequence
>6me2A (length=486) Species: 9606,272844 [Search protein sequence]
RPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAV
ANLVVAIYPYPLVLMSIFNNGWNFGYLHCQVSAFLMGLSVIGSIWNITGI
AIDRYLYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYD
PRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRGID
CSFWNESYLTGSRDERKKSLLSKFGMDEGVTFMFIGRFDRGQKGVDVLLK
AIEILSSKKEFQEMRFIIIGKGDPELEGWARSLEEKHGNVKVITEMLSRE
FVRELYGSVDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNE
TGILVKAGDPGELANAILKALELSRSDLSKFRENCKKRAMSFSKLKPQDF
RNFVTMFVVFVLFAICFAPLNFIGLAVASDPASMVPRIPEWLFVASYYMA
YFNSCLNPIIYGLLDQNFRKEYRRIIVSLCTARVFF
3D structure
PDB6me2 Structural basis of ligand recognition at the human MT1melatonin receptor.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JEV A M107 G108 N162 F179 Q181 V191 L254 M86 G87 N141 F158 Q160 V170 L420 PDBbind-CN: -logKd/Ki=9.37,Ki=0.43nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0008502 melatonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6me2, PDBe:6me2, PDBj:6me2
PDBsum6me2
PubMed31019306
UniProtP48039|MTR1A_HUMAN Melatonin receptor type 1A (Gene Name=MTNR1A);
Q9V2J8

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