Structure of PDB 6mdw Chain A

Receptor sequence
>6mdwA (length=185) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSLVDASWELVDPTPDLQALFVQFNDQFFWGQLEAVEVKWSVRMTLCAG
ICSYEGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREG
HGPEFCKHMHRINSLTGANITVYHTFHDEVDEYRRHWWRCNGPCQHRPPY
YGYVKRATNREPSAHDYWWAEHQKTCGGTYIKIKE
3D structure
PDB6mdw Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L74 Y179 Y182 V183 R189 Y196 W197 Y209 L47 Y150 Y153 V154 R160 Y167 W168 Y180
BS02 ZN A C169 C173 H201 C205 C140 C144 H172 C176
BS03 ZN A H111 H115 H130 H82 H86 H101
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006974 DNA damage response

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Molecular Function
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Biological Process
External links
PDB RCSB:6mdw, PDBe:6mdw, PDBj:6mdw
PDBsum6mdw
PubMed30893605
UniProtQ9H040|SPRTN_HUMAN DNA-dependent metalloprotease SPRTN (Gene Name=SPRTN)

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