Structure of PDB 6mda Chain A

Receptor sequence
>6mdaA (length=468) Species: 9606 (Homo sapiens) [Search protein sequence]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSNPGDFTLSVRRNGAVTHIK
IQNTGDYYDLYGGEKFATLAELVQYYMEHIELKYPLNCADPTSERWFHGH
LSGKEAEKLLTEKGKHGSFLVREPGDFVLSVRTGDSKVTHVMIRCQELKY
DVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESR
VRELSKLQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDH
TRVVLHSDYINANIIMPKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTT
KEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVG
QGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVV
HCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQT
EAQYRFIYMAVQHYIETL
3D structure
PDB6mda Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
ChainA
Resolution2.21 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D425 C459 R465 T466 Q506
Catalytic site (residue number reindexed from 1) D368 C402 R408 T409 Q449
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JED A R111 H114 N217 T218 T219 E250 T253 L254 P491 R95 H98 N188 T189 T190 E213 T216 L217 P434
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6mda, PDBe:6mda, PDBj:6mda
PDBsum6mda
PubMed30688462
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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