Structure of PDB 6mbl Chain A

Receptor sequence

>6mblA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVT
FDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELF
LWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNS
FWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYF
YKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLAL
IPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAE
FVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFAL
HFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSW
DNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLG
EKEILEKAVKSAAVNREYYRQQMEEKAPLPK

3D structure

PDB

6mbl SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

Chain

Resolution

2.197 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.85: protein-histidine N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M151 N153 N211 V247 Q254 N255 P258 W273 D274 T285 G286 Y287 Y312 R315	M132 N134 N192 V228 Q235 N236 P239 W254 D255 T266 G267 Y268 Y293 R296
BS02	SAH	A	R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326 F328	R55 E84 F86 R234 D255 M256 N258 H259 Y293 S305 F307 F309

Gene Ontology

	Molecular Function
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008170	N-methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016279	protein-lysine N-methyltransferase activity
GO:0018064	protein-L-histidine N-tele-methyltransferase activity
GO:0042800	histone H3K4 methyltransferase activity
GO:0046975	histone H3K36 methyltransferase activity
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding

	Biological Process
GO:0006338	chromatin remodeling
GO:0018021	peptidyl-histidine methylation
GO:0018023	peptidyl-lysine trimethylation
GO:0030047	actin modification
GO:0032259	methylation
GO:0045893	positive regulation of DNA-templated transcription
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0051149	positive regulation of muscle cell differentiation
GO:0070472	regulation of uterine smooth muscle contraction

	Cellular Component
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6mbl, PDBe:6mbl, PDBj:6mbl
PDBsum	6mbl
PubMed	30626964
UniProt	Q86TU7\|SETD3_HUMAN Actin-histidine N-methyltransferase (Gene Name=SETD3)

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