Structure of PDB 6max Chain A

Receptor sequence
>6maxA (length=111) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
AHHHERLRLRRDFLLIFKEGKSLQNEYFVVLFRKNGLDYSRLGIVVKRKF
GKATRRNKLKRWVREIFRRNKGVIPKGFDIVVIPRKKLSEEFERVDFWTV
REKLLNLLKRI
3D structure
PDB6max A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor.
ChainA
Resolution1.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9TF A Q28 V33 R89 Q24 V29 R85 MOAD: Ki=1.9uM
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004526 ribonuclease P activity
GO:0042781 3'-tRNA processing endoribonuclease activity
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0008033 tRNA processing
GO:0042780 tRNA 3'-end processing
Cellular Component
GO:0030677 ribonuclease P complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6max, PDBe:6max, PDBj:6max
PDBsum6max
PubMed30997498
UniProtQ9X1H4|RNPA_THEMA Ribonuclease P protein component (Gene Name=rnpA)

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