Structure of PDB 6maj Chain A

Receptor sequence
>6majA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
SMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRH
MAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTL
YYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQ
GYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNF
QGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEW
IAKENKTMDPSCLKWTP
3D structure
PDB6maj HBO1 is required for the maintenance of leukaemia stem cells.
ChainA
Resolution2.139 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F534 K537 E538 I539 S540 I541 K542 H572 L573 V574 K576 F200 K203 E204 I205 S206 I207 K208 H238 L239 V240 K242
BS02 ZN A C368 C371 H384 C388 C34 C37 H50 C54
BS03 JAV A T477 R483 G485 G487 K488 S512 L514 G515 S518 E525 T143 R149 G151 G153 K154 S178 L180 G181 S184 E191 PDBbind-CN: -logKd/Ki=7.47,Kd=0.034uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6maj, PDBe:6maj, PDBj:6maj
PDBsum6maj
PubMed31827282
UniProtO95251|KAT7_HUMAN Histone acetyltransferase KAT7 (Gene Name=KAT7)

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