Structure of PDB 6ma2 Chain A

Receptor sequence

>6ma2A (length=697) Species: 9606 (Homo sapiens) [Search protein sequence]

CPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQ
QQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI
QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC
LQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKA
IAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSH
LMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNG
KAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGAL
FMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVID
FKIYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMIN
RGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDA
IVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQ
NMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGT
PMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLK
KVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK

3D structure

PDB

6ma2 Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	D318 N321 N322 N325 N356 Q362 F384 D386 N390 N393 K396 Q399 F418 D420 N424 D431 D454 N458 H496 H499 K634	D6 N9 N10 N13 N44 Q50 F72 D74 N78 N81 K84 Q87 F106 D108 N112 D119 D142 N146 H184 H187 K322
BS02	J9S	A	N557 H558 P559 H562 L866 F868 V895 A896 K898 H901	N245 H246 P247 H250 L535 F537 V564 A565 K567 H570	MOAD: Kd=4.1uM PDBbind-CN: -logKd/Ki=5.39,Kd=4.1uM

External links

PDB	RCSB:6ma2, PDBe:6ma2, PDBj:6ma2
PDBsum	6ma2
PubMed	30285435
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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