Structure of PDB 6ma1 Chain A

Receptor sequence
>6ma1A (length=697) Species: 9606 (Homo sapiens) [Search protein sequence]
CPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQ
QQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI
QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHC
LQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKA
IAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSH
LMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNG
KAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGAL
FMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVID
FKIYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMIN
RGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDA
IVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQ
NMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGT
PMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLK
KVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB6ma1 Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N325 N356 S359 Q362 F384 D386 N390 N393 F418 D420 N424 K430 D431 F452 D454 N458 N13 N44 S47 Q50 F72 D74 N78 N81 F106 D108 N112 K118 D119 F140 D142 N146
BS02 JA4 A H558 P559 H562 Q839 L866 F868 V895 A896 K898 H901 R904 H246 P247 H250 Q508 L535 F537 V564 A565 K567 H570 R573 PDBbind-CN: -logKd/Ki=8.10,Kd=0.008uM
External links
PDB RCSB:6ma1, PDBe:6ma1, PDBj:6ma1
PDBsum6ma1
PubMed30285435
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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