Structure of PDB 6m9t Chain A

Receptor sequence
>6m9tA (length=444) Species: 9606,10665 [Search protein sequence]
DCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWL
ALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSL
FIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLG
VGQYTVQWPGTWCFISTNWGNLFFASAFAFLGLLALTVTFSCNLATIKAL
VSRGSNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSEL
DKAIGRNTNGVITKDEAEKLFNQDVDATVRGILRNAKLKPVYDSLDAVRR
AALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRA
KRVITTFRTGTWDAYGSWGRITTETAIQLMAIMCVLSVCWSPLLIMMLKM
IFNEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILGRPLEVL
3D structure
PDB6m9t Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J9P A T106 T107 Y114 M137 F140 G141 T206 W207 L329 R333 S336 Q339 T61 T62 Y69 M92 F95 G96 T161 W162 L413 R417 S420 Q423 PDBbind-CN: -logKd/Ki=7.70,Ki=19.9nM
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:6m9t, PDBe:6m9t, PDBj:6m9t
PDBsum6m9t
PubMed30510194
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P43115|PE2R3_HUMAN Prostaglandin E2 receptor EP3 subtype (Gene Name=PTGER3)

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