Structure of PDB 6m93 Chain A

Receptor sequence
>6m93A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFKPPNSFYRALYPKIIQDIET
IESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKN
TLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIH
HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNV
VDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVS
GSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVW
DLVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD
FL
3D structure
PDB6m93 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y271 R285 S309 S325 L351 A391 N394 R474 Y488 R521 F523 Y126 R140 S164 S180 L206 A246 N249 R329 Y343 R376 F378
BS02 J8Y A N394 R431 G432 I433 A434 S448 N249 R286 G287 I288 A289 S303
External links
PDB RCSB:6m93, PDBe:6m93, PDBj:6m93
PDBsum6m93
PubMed30926793
UniProtQ9Y297|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)

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