Structure of PDB 6m91 Chain A

Receptor sequence
>6m91A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDIETI
ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNT
LECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHH
CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV
DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSG
SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD
LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF
LN
3D structure
PDB6m91 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y271 R285 S309 L311 S325 L351 K365 A392 N394 G408 R474 Y488 F523 Y125 R139 S163 L165 S179 L205 K219 A246 N248 G262 R328 Y342 F377
BS02 J97 A N394 R410 R431 G432 S448 Y488 N248 R264 R285 G286 S302 Y342
External links
PDB RCSB:6m91, PDBe:6m91, PDBj:6m91
PDBsum6m91
PubMed30926793
UniProtQ9Y297|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)

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