Structure of PDB 6m90 Chain A

Receptor sequence
>6m90A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
SMLQRDFITALPARGLDHIAENILSYLDAKSLCAAELVCKEWYRVTSDGM
LWKKLIERMVRTDSLWRGLAERRGWGQYLFPPNSFYRALYPKIIQDIETI
ESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNT
LECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHH
CEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV
DFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSG
SSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWD
LVAALDPRAPAGTLCLRTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWDF
LN
3D structure
PDB6m90 Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y271 R285 S309 S325 L351 K365 N394 R474 Y488 R521 F523 Y125 R139 S163 S179 L205 K219 N248 R328 Y342 R375 F377
BS02 J91 A N394 G408 R410 R431 G432 A434 S448 N248 G262 R264 R285 G286 A288 S302
External links
PDB RCSB:6m90, PDBe:6m90, PDBj:6m90
PDBsum6m90
PubMed30926793
UniProtQ9Y297|FBW1A_HUMAN F-box/WD repeat-containing protein 1A (Gene Name=BTRC)

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