Structure of PDB 6m8q Chain A

Receptor sequence
>6m8qA (length=451) Species: 9606 (Homo sapiens) [Search protein sequence]
SDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDL
IDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLS
DYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGH
VLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYG
THIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQ
NHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHI
SNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYC
VEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRA
LKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNF
R
3D structure
PDB6m8q CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
ChainA
Resolution2.49 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.27.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D75 H76 D179 H418 D67 H68 D171 H410
BS02 ZN A H71 H73 H158 D179 H63 H65 H150 D171
BS03 JBG A P45 L47 E48 Y110 V240 F241 P329 G330 M331 Q333 G356 P37 L39 E40 Y102 V232 F233 P321 G322 M323 Q325 G348 PDBbind-CN: -logKd/Ki=6.43,Kd=370nM
External links
PDB RCSB:6m8q, PDBe:6m8q, PDBj:6m8q
PDBsum6m8q
PubMed31819276
UniProtQ9UKF6|CPSF3_HUMAN Cleavage and polyadenylation specificity factor subunit 3 (Gene Name=CPSF3)

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