Structure of PDB 6m7v Chain A

Receptor sequence

>6m7vA (length=422) Species: 9606 (Homo sapiens)

HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEV
MEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEG
LPQGKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFS

3D structure

• PDB: 6m7v Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
• Chain: A
• Resolution: 3.062 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I114 E116 K224 S257 L258 G259 K261 L262 R382	I115 E117 K216 S249 L250 G251 K253 L254 R374
BS02	dna	A	K86 K293 K311 K317 G320 C321 S322 N324 R351	K87 K285 K303 K309 G312 C313 S314 N316 R343
BS03	DZ4	A	D13 M14 C16 F18 I48 Y52 R55 D115	D14 M15 C17 F19 I49 Y53 R56 D116
BS04	MN	A	D13 M14 D115	D14 M15 D116
BS05	MN	A	D13 D115 E116	D14 D116 E117

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6m7v, PDBe:6m7v, PDBj:6m7v
• PDBsum: 6m7v
• PubMed: 30275308
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)