Structure of PDB 6m7u Chain A

Receptor sequence

>6m7uA (length=417) Species: 9606 (Homo sapiens)

HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRF
AVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGVQK
EGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCS
AGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLG
ASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPR
QLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVA
TQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQT
EWSPPLTMLFLCATKFS

3D structure

• PDB: 6m7u Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
• Chain: A
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	S113 E116 K224 S257 G259 G260 K261 L262 R382	S107 E110 K211 S244 G246 G247 K248 L249 R369
BS02	dna	A	Q38 K40 I48 S62 K293 K317 T318 G320 C321 S322 K323 N324 R351	Q39 K41 I49 S63 K280 K304 T305 G307 C308 S309 K310 N311 R338
BS03	1FZ	A	M14 C16 F18 I48 Y52 R61 D115 K231	M15 C17 F19 I49 Y53 R62 D109 K218
BS04	MG	A	D13 M14 D115	D14 M15 D109

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:6m7u, PDBe:6m7u, PDBj:6m7u
• PDBsum: 6m7u
• PubMed: 30275308
• UniProt: Q9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)