Structure of PDB 6m3s Chain A

Receptor sequence
>6m3sA (length=333) Species: 339 (Xanthomonas campestris) [Search protein sequence]
QTITVIRGDGIGPEIMDATLFVLDALQAGLTYEYADAGLVALEKHGDLLP
ESTLASITKNKVALKSPLTTPVGEGFSSINVAMRRKFDLYANVRPAKSFP
NTKSRFADGVDLITVRENTEGAYLSEGQEVSADGEVAVSGARVTRKGSER
IVRYAFDLARATGRKKVTAVHKANIIKSTSGLFLKVARDVATQYPEIEFQ
EMIVDNTCMQLVMRPEQFDIIVTTNLFGDIISDLCAGLVGGLGLAPGANI
GVDAAIFEAVHGSAPDIAGQGKANPCALLLGAAQMLDHIGQPQNAERLRE
AIVATLEAKDSLTPDLGGTGNTMGFAKAIASRL
3D structure
PDB6m3s Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y125 K174 D207 D231
Catalytic site (residue number reindexed from 1) Y123 K172 D205 D229
Enzyme Commision number 1.1.1.41: isocitrate dehydrogenase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A P69 L70 T72 N82 L244 E260 H263 G264 S265 A266 D268 N276 P67 L68 T70 N80 L242 E258 H261 G262 S263 A264 D266 N274
BS02 ICA A T72 S80 N82 R86 R96 R118 Y125 D231 T70 S78 N80 R84 R94 R116 Y123 D229
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004449 isocitrate dehydrogenase (NAD+) activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6m3s, PDBe:6m3s, PDBj:6m3s
PDBsum6m3s
PubMed
UniProtA0A0H2XBX7

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