Structure of PDB 6m2v Chain A

Receptor sequence
>6m2vA (length=192) Species: 10090 (Mus musculus) [Search protein sequence]
IVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLV
LAGGYEDDVDNGNYFTYTGSGSSDQKLTNNNRALALNCHSPINEKGAEAE
DWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVVKYWPERFLVWRYL
LRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLEALANKEKS
3D structure
PDB6m2v Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F437 R438 V451 A452 G453 A468 G469 G470 Y471 Y483 T484 K544 F21 R22 V35 A36 G37 A52 G53 G54 Y55 Y67 T68 K115
BS02 dna A R448 H450 H455 R457 S458 R32 H34 H39 R41 S42
External links
PDB RCSB:6m2v, PDBe:6m2v, PDBj:6m2v
PDBsum6m2v
PubMed33359809
UniProtQ8VDF2|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Gene Name=Uhrf1)

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