Structure of PDB 6m22 Chain A

Receptor sequence
>6m22A (length=885) Species: 9606 (Homo sapiens) [Search protein sequence]
YTNLTQGAKEHEEQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAGVLQA
FAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGL
CFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRV
YGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPP
HFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNSSQFFNATC
DEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSSDVLG
SLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGT
ILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPW
VIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPT
WALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLRTP
NWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQ
GAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLH
VKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQTIKHLMEA
EKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNGWRQSEDA
RAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDG
GMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIE
AEVEVVEMHDSDISNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPRNP
EGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
3D structure
PDB6m22 Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL A G447 M449 G328 M330
BS02 CL A G150 S444 G31 S325
BS03 EZC A L615 R617 R693 L496 R498 R574
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0007268 chemical synaptic transmission
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071477 cellular hypotonic salinity response
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m22, PDBe:6m22, PDBj:6m22
PDBsum6m22
PubMed33199848
UniProtQ9UHW9|S12A6_HUMAN Solute carrier family 12 member 6 (Gene Name=SLC12A6)

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