Structure of PDB 6m1y Chain A

Receptor sequence
>6m1yA (length=938) Species: 9606 (Homo sapiens) [Search protein sequence]
NRMANYTNLTQGAKEHEEAENQMGTFMGVYLPCLQNIFGVILFLRLTWVV
GTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGP
EFGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFHSDDALKESA
AMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASLFLACVIVSILAIYAGA
IKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCNS
SQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPS
AKSSDVLGSLNHEYVLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDA
QKSIPIGTILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVG
TLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGH
SKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACA
LQTLLRTPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGM
IYKYIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVL
LKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVGNFLENYGEALAAEQ
TIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPN
GWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNID
VWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLAT
FLYHLRIEAEVEVVEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERD
REAQLVKDRNSVHMTWTKVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPP
RNPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS
3D structure
PDB6m1y Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL A G447 M449 Y603 G336 M338 Y492
BS02 CL A G150 I152 P443 G39 I41 P332
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0007268 chemical synaptic transmission
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0071333 cellular response to glucose stimulus
GO:0071477 cellular hypotonic salinity response
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m1y, PDBe:6m1y, PDBj:6m1y
PDBsum6m1y
PubMed33199848
UniProtQ9UHW9|S12A6_HUMAN Solute carrier family 12 member 6 (Gene Name=SLC12A6)

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