Structure of PDB 6m1i Chain A

Receptor sequence
>6m1iA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKIFKKEQAMCLEKIQRAPGCPGMWDNITCWKPAHVGEMVLVSCPELFR
IFNPDQDMGVVSRNCTGWSEPFPHYFDACGFDEGDQDYYYLSVKALYTVG
YSLSLVALLLAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWIL
YAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFF
PERRYFYWYTIIGWGAPLVFVTVWATLRLYFDDTGCWDMNDSTALWWVIK
GPVVGSIMVNFVLFIGIIVILVQKLQSPDSIYLRLARSTLLLIPLFGIHY
TVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWR
SWK
3D structure
PDB6m1i Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D23 F27 I61 I83 F84 D147 Y150 Y157 R199 L210 D215 C219 V237 D298 M299 D301 W306 L382 L386 D1 F5 I29 I51 F52 D87 Y90 Y97 R139 L150 D155 C159 V177 D238 M239 D241 W246 L316 L320
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6m1i, PDBe:6m1i, PDBj:6m1i
PDBsum6m1i
PubMed32047270
UniProtP41586|PACR_HUMAN Pituitary adenylate cyclase-activating polypeptide type I receptor (Gene Name=ADCYAP1R1)

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