Structure of PDB 6m0p Chain A

Receptor sequence

>6m0pA (length=503) Species: 915 (Nitrosomonas europaea) [Search protein sequence]

DISTVPDETYDALKLDRGKATPKETYEALVKRYKDPAHGAGKGTMGDYWE
PIAISIYMDPNTFYKPPVSPKEVAERKDCVECHSDETPVWVRAWKRSTHA
NLDKIRNLKSDDPLYYKKGKLEEVENNLRSMGKLGEKETLKEVGCIDCHV
DVNKKDKADHTKDIRMPTADTCGTCHLREFAERESERDTMVWPNGQWPAG
RPSHALDYTANIETTVWAAMPQREVAEGCTMCHTNQNKCDNCHTRHEFSA
AESRKPEACATCHSGVDHNNWEAYTMSKHGKLAEMNRDKWNWEVRLKDAF
SKGGQNAPTCAACHMEYEGEYTHNITRKTRWANYPFVPGIAENITSDWSE
ARLDSWVLTCTQCHSERFARSYLDLMDKGTLEGLAKYQEANAIVHKMYED
GTLTGQKTNRPNPPEPEKPGFGIFTQLFWSKGNNPASLELKVLEMAENNL
AKMHVGLAHVNPGGWTYTEGWGPMNRAYVEIQDEYTKMQELSALQARVNK
LEG

3D structure

PDB

6m0p Enhancement of the activity of hydroxylamine oxidoreductase by juglone, plant secondary metabolite.

Chain

Resolution

2.78 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H257 D291 H292 Y358 Y491
Catalytic site (residue number reindexed from 1)	H233 D267 H268 Y334 Y467
Enzyme Commision number	1.7.2.6: hydroxylamine dehydrogenase. 1.7.2.9: hydroxylamine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEC	A	Y140 K141 H200 E203 H228 C263 C266 H267 S277 R278 R319 L320 M339 H347	Y116 K117 H176 E179 H204 C239 C242 H243 S253 R254 R295 L296 M315 H323
BS02	HEC	A	T122 H123 K141 K144 V167 C196 C199 H200 C263 H267 F272	T98 H99 K117 K120 V143 C172 C175 H176 C239 H243 F248
BS03	HEC	A	Y81 Y88 A98 C103 C106 H107 E110 C169 H173 H184 I188 M190	Y57 Y64 A74 C79 C82 H83 E86 C145 H149 H160 I164 M166
BS04	HEC	A	Y81 H107 W114 W118 H123 V167 G168 C169 C172 H173 M190 P191 K262 D264 R269 H270 F272	Y57 H83 W90 W94 H99 V143 G144 C145 C148 H149 M166 P167 K238 D240 R245 H246 F248
BS05	HEC	A	H287 N294 Y298 H303 P332 T333 C334 C337 H338 T353 R354 W355 W380 M400 A482 H483	H263 N270 Y274 H279 P308 T309 C310 C313 H314 T329 R330 W331 W356 M376 A458 H459
BS06	HEC	A	P226 S227 H228 D231 C256 H257 N259 N265 C266 C283 C286 H287 C334 I349 T353 A356	P202 S203 H204 D207 C232 H233 N235 N241 C242 C259 C262 H263 C310 I325 T329 A332
BS07	HEC	A	H303 N330 A331 P332 C384 C387 H388 F392 Y396 V484	H279 N306 A307 P308 C360 C363 H364 F368 Y372 V460
BS08	ISW	A	W221 R225 A234 N235 T238 W241 C253 C256 H257 C286 H287 H292 N357 Y358 F452	W197 R201 A210 N211 T214 W217 C229 C232 H233 C262 H263 H268 N333 Y334 F428
BS09	HEC	A	W114 M255 K262 D264 T268 R269	W90 M231 K238 D240 T244 R245
BS10	HEC	A	H388 S389 F392	H364 S365 F368

External links

PDB	RCSB:6m0p, PDBe:6m0p, PDBj:6m0p
PDBsum	6m0p
PubMed	38009977
UniProt	Q50925\|HAO_NITEU Hydroxylamine oxidoreductase (Gene Name=hao1)

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